Molecular Formula | C11H18N4O2 |
Molar Mass | 238.29 |
Density | 1.1387 (rough estimate) |
Melting Point | 90.5°C |
Boling Point | 380.88°C (rough estimate) |
Flash Point | >100°C |
Water Solubility | 3060 mg l-1 |
Vapor Presure | 2.1 x 10-3 Pa (30 °C) |
Appearance | neat |
Merck | 13,7579 |
BRN | 663442 |
pKa | 4.34 (weak base) |
Storage Condition | APPROX 4°C |
Refractive Index | 1.6081 (estimate) |
Physical and Chemical Properties | Melting Point: 90.5
|
Use | It is a kind of special effect on aphids, which has the effect of contact and fumigation. |
Risk Codes | R25 - Toxic if swallowed R50/53 - Very toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment. R36 - Irritating to the eyes R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
Safety Description | S22 - Do not breathe dust. S37 - Wear suitable gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S60 - This material and its container must be disposed of as hazardous waste. S61 - Avoid release to the environment. Refer to special instructions / safety data sheets. S36 - Wear suitable protective clothing. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. |
UN IDs | UN 2811 |
WGK Germany | 3 |
RTECS | EZ9100000 |
Hazard Class | 6.1(b) |
Packing Group | III |
Toxicity | LD50 orally in female rats: 147 (mg/kg) (Baranyovits, Ghosh) |
NIST chemical information | Information provided by: webbook.nist.gov (external link) |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
toxicity | acute oral LD50 in rats is 68~147 mg/kg, while that in mice is 107 mg/kg. Acute percutaneous LD50>500mg/kg in rats. The 2-year chronic toxicity test showed that the non-effective dose was 12.5 mg/kg per day in rats and 1.8 mg/kg in dogs. It has no teratogenic, carcinogenic and mutagenic effects on animals. No abnormalities were found in the three-generation reproduction and neurotoxicity tests. Most fish LC50 is 32~40mg/kg, which is safe for bees. |
use | efficient and selective aphid killer. It has contact killing, fumigation, and internal absorption, and has permeability to the leaf surface. It is used to control aphids on grains, fruit trees, vegetables, and flowers, such as control of aphids on cabbage, cabbage, beans, tobacco, and hemp seedlings, and spray 2000-4000 times with 50% wettable powder. Anti-aphidb is basically ineffective against cotton aphids. This product is a high-efficiency specific acaricide, which has the effects of contact killing, fumigation killing, and internal absorption and penetration, and still has a killing effect on aphids that produce resistance to organic phosphorus. It is a kind of systemic carbamate insecticide with special effects on aphids. It has contact killing and fumigation effects Antiaphidocarb is a high-efficiency specific acaricide, which has contact killing, fumigation, and internal absorption and penetration effects. It can throw and kill the aphids that produce resistance to organic phosphorus. |
Production method | 2-(N,N-dimethylamino)-5, 6-dimethyl-4-hydroxypyrimidine is synthesized from the reaction of asymmetric dimethylguanidine sulfate and ethyl α-methylacetoacetate at 60°C for 2h. In benzene, it reacts with phosgene at low temperature, and finally reacts with dimethylamine to obtain antiaphidicarb. Preparation method N,N-dimethylguanidine is prepared by the reaction of thiourea and dimethyl sulfate, and then reacted with dimethylamine or dimethylamine hydrochloride to prepare N,N-dimethylguanidine. Preparation of ethyl α-methyl acetoacetate Ethyl acetoacetate was methylated with dimethyl sulfate or methyl iodide to produce ethyl α-methyl acetoacetate. Ethyl α-methylacetoacetate can also be prepared by ethyl dimethylaminobutenoic acid. The reaction process is as follows: (95%)(80%) Preparation of 2-dimethylamino -5, 6-dimethyl-4-hydroxypyrimidine 14gN,N-dimethylguanidine (sulfate), 4.6g of acid binding agent and alcohol are mixed, stirred for 2h, α-methylacetoacetyl ethyl ester and solvent are added, and the temperature is slowly increased under stirring, react at about 140 ℃ for 2 hours, recover the solvent under reduced pressure, dissolve the solid with chloroform and adjust the pH value to 7, concentrate chloroform to dry, and obtain 15.7g of product with a content of 92. 69%, yield 93.43%. 2-Dimethylamino-5, 6-dimethyl-4-hydroxypyrimidine can also be prepared by reacting with formaldehyde under pressurized conditions with zinc acetate as a catalyst. The synthesis of anti-aphidocarb adopts the general synthesis method of carbamate pesticides: preparation method 2: adding 7.1 g5, 6-dimethyl-2-dimethylamino-4-hydroxypyrimidine and 4.3g triethylamine benzene solution (100mL) into 35mL benzene solution containing 12.5% phosgene, reacting at 5-8 ℃ for 45min, adding 10mL aqueous solution containing 3.9g dimethylamine dropwise, stirring, and the reaction temperature is less than 10 ℃. Then stir at 10 ℃ for more than 30min, add 50mL of water until the solid is completely dissolved. Benzene is separated, washed with water, and saturated Na2CO3 solution is added to obtain anti-aphid, m.p.88 ~ 90 ℃. |
category | pesticide |
toxicity classification | highly toxic |
acute toxicity | oral-rat LD50: 100 mg/kg; Oral-mouse LD50: 107 mg/kg |
flammability hazard characteristics | combustion produces toxic nitrogen oxide gas |
storage and transportation characteristics | warehouse ventilation and low temperature drying; separate from food raw materials storage and transportation |
fire extinguishing agent | dry powder, foam, sand |
occupational standard | STEL 0.05 mg/m3 |
toxic substance data | information provided by: pubchem.ncbi.nlm.nih.gov (external link) |